Product Code: ICA12_M201

Variation of Biocompatibility of Titanium Dioxide Film by Femtosecond Laser Irradiation
Authors:
Togo Shinonaga, Graduate School of Engineering, Osaka Univ.; Suita, Osaka Japan
Masahiro Tsukamoto, Joining and Welding Research Institute, Osaka Univ.; Ibaraki, Osaka Japan
Naoto Horigutchi, Graduate School of Engineering, Osaka Univ.; Suita, Osaka Japan
Yuichiro Ito, Graduate School of Engineering, Osaka Univ.; Suita, Osaka
Akiko Nagai, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Unive.; Chiyoda-Ku, Tokyo Japan
Kimihiro Yamashita, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ.; Chiyoda-Ku, Tokyo Japan
Takao Hanawa, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ.; Chiyoda-Ku, Tokyo Japan
Nobuhiro Matsushita, Materials and Structures Laboratory, Tokyo Institute of Technology; Yokohama, Kanagawa Japan
Xie Guoqiang, Institute for Materials Research, Tohoku Univ.; Sendai, Miyagi Japan
Masanari Takahashi, Osaka Municipal Technical Research Institute; Joto-Ku, Osaka, Osaka Japan
Nobuyuki Abe, Joining and Welding Research Institute, Osaka Univ.; Ibaraki, Osaka Japan
Presented at ICALEO 2012

Titanium (Ti) is one of the most widely used for biomaterials, because of their excellent anti-corrosion and mechanical properties. It is well known that microstructures formation and coating of the titanium dioxides (TiO2) on Ti surface is one of the useful methods to improve its biocompatibility. Biocompatibility of TiO2 film is also improved by creation of oxygen deficiencies in the TiO2 film with UV light illumination. We have developed coating method of TiO2 film on Ti plate with an aerosol beam. In our previous study, oxygen deficiencies were created in TiO2 film after femtosecond laser irradiation. Microstructures can be also formed on TiO2 film by femtosecond laser irradiation. Thus, biocompatibility of TiO2 film after oxygen deficiencies and microstructures formation with femtoescond laser could be more improved than that of bare TiO2 film. In this study, we report the variation of biocompatibility of TiO2 film by femtosecond laser irradiation. The wavelength, pulse duration and repetition rate of the femtosecond laser were 775 nm, 150 fs and 1 kHz, respectively. Oxygen deficiencies and topography of TiO2 film was varied by controlling the laser fluence. The biocompatibility, including the cell responses, of TiO2 film after femtosecond laser irradiation was investigated.