Product Code: ILSC2011_803

Minimum Visible Lesion (MVL) Thresholds in Cynomolgus (Macaca Fasicularis) Retina Resulting from Laser Exposure at Wavelengths of 413-nm, 532-nm and 647-nm
Authors:
Jeffrey W. Oliver, Air Force Research Laboratory, AFRL/711 HPW/RHDO; Cedar Park TX USA
Benjamin A. Rockwell, Air Force Research Laboratory, AFRL/711 HPW/RHDO; Brooks City-Base TX USA
Semih S. Kumru, Air Force Research Laboratory, AFRL/711 HPW/RHDO; Brooks City-Base TX USA
Clifton D. Clark, TASC, Inc.; San Antonio TX USA
Harvey M. Hodnett, TASC, Inc.; San Antonio TX USA
Gary D. Noojin, TASC, Inc.; San Antonio TX USA
Kurt J. Schuster, TASC, Inc.; San Antonio TX USA
David J. Stolarski, TASC, Inc.; San Antonio TX USA
Presented at ILSC 2011

In order to explore the alternative use of cynomolgus (Macaca fasicularis) as a substitute for the ubiquitous rhesus monkey (Macaca mulatta) as a model for retinal damage, a series of bridging experiments utilizing visible lasers (413 nm, 532 nm and 647 nm) has been completed. Exposure conditions conducive to both photochemical and photothermal damage mechanisms were explored with parameters that were similar to those used in previous studies which had employed the Rhesus model. At the 413-nm wavelength, extended-source (subtending 1.0 degree of visual field) exposures of 0.1 sec and 20 sec at the retina were investigated fundoscopically resulting in ED50 MVL damage thresholds of 127 mW and 2.9 mW, respectively. With the 532-nm laser, exposures of 0.1 sec resulted in an ED50 damage threshold of 13.0 mW; and finally, with the 647-nm laser, 5.0 sec exposures resulted in a damage threshold of 5.4 mW. These findings are compared with results from previous studies and recommendations for additional studies are indicated.